JMJD2B Antibody

Catalog Number:

24959

Amount:

100μg

Price:

$319

Swiss-Prot No:

AAI36612

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide from near the center of human JMJD2B.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

Applications:

ELISA WB

Background:

Members of the Jumonji domain 2 (JMJD2) family contain a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. Like other members of the JMJD1 and JMJD2 families, JMJD2B is a histone demethylase, but is reported to be a very poor enzyme. Similar to JMJD1A, JMJD2B is a transcriptional target of the hypoxia-inducible factor (HIF), and hypoxic cells express elevated levels of the JMJD2B mRNA and protein. Both JMJD1A and JMJD2B retain their histone demethylase activity in hypoxic conditions, suggesting that this activity of JMJD2B might play a role in the hypoxic gene expression program.

References:

appl_detail:

Datasheet PDF