CAPS1 Antibody

Catalog Number:

24669

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9ULU8
Gene ID:8618

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 21 amino acid peptide near the amino terminus of the human CAPS1.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

Numerous isoforms of CAPS1 are known to exist. This CAPS1 antibody is predicted to be specific to CAPS1 and not recognize CAPS2.

Applications:

ELISA WB IHC

Background:

CAPS1 and its related protein CAPS2 encode novel neural/endocrine-specific cytosolic and peripheral membrane proteins. Both are essential components of the synaptic vesicle priming machinery and are required for the Ca2+-regulated exocytosis of secretory vesicles; CAPS-deficienct neurons contain no or very few fusion competent synaptic vesicles, causing a selective impairment of fast phasic transmitter release. CAPS1 acts at a stage in exocytosis that follows ATP-dependent priming, which involves the essential synthesis of phosphatidylinositol 4, 5-bisphosphate and is thought to be a specific regulator of large dense-core vesicle fusion.

References:

appl_detail:

Datasheet PDF