ATG5 Antibody

Catalog Number:

24623

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:A9UGY9
Gene ID:9474

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide from near the amino terminus of human ATG5.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

Three isoforms of ATG5 are known to exist; this ATG5 antibody will only detect the longest isoform.

Applications:

ELISA WB IHC

Background:

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG5, another member of the autophagy protein family, forms a conjugate with ATG12; this conjugate has a ubiquitin-protein ligase (E3)-like activity for protein lipidation in autophagy. This conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells.

References:

appl_detail:

Datasheet PDF