STEAP1 Antibody

Catalog Number:

24566

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9UHE8
Gene ID:26872

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide from near the center of human STEAP1.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This STEAP1 antibody does not cross-react with other STEAP proteins.

Applications:

ELISA WB IHC

Background:

The six-transmembrane epithelial antigen of prostate 1 (STEAP1) was the first member of a family of metalloreductases identified as cell-surface antigens in prostate tissue. The normal function of STEAP is still uncertain; unlike other members of the STEAP family, STEAP1 does not promote iron or copper reduction or uptake and lacks the FNO-like reductase domain critical for activity. However, its expression is highly increased in multiple cancer cell lines, including prostate, bladder, colon, and ovarian cancers. Supporting this is evidence that STEAP1 peptides can be used to stimulate CD8+ T cells from healthy donors, enabling them to recognize STEAP1-positive human tumor cells, suggesting that STEAP1 may a potential target for cancer immunotherapy. At least three isoforms of STEAP1 are known to exist.

References:

appl_detail:

Datasheet PDF