NogoA Antibody

Catalog Number:

24516

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9NQC3
Gene ID:57142

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 19 amino acid peptide from near the center of human NogoA.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

At least five isoforms of Nogo are known to exist; this antibody is specific for NogoA and NogoE.

Applications:

ELISA WB IHC

Background:

NogoA is a member of a family of integral membrane proteins termed reticulons that are thought to be involved in numerous disorders including neurodegenerative diseases. Reticulon proteins are known to regulate many cellular processes and interact with multiple proteins and receptors such as BACE. NogoA was initially identified as a myelin-associated neurite outgrowth inhibitor. It is highly expressed in oligodendrocytes in the white matter of the CNS; blocking its activity with antibodies or other factors results in improved axon regrowth and functional recovery in experimental CNS lesion models. NogoA has also been suggested to play a role in neurodegenerative diseases such as Amyotrophic lateral sclerosis, in which case NogoA is found at elevated levels in postmortem muscular samples, and multiple sclerosis (MS), in which case autoantibodies to NogoA have been found in serum and cerebrospinal fluid in MS patients.

References:

appl_detail:

Datasheet PDF