TRPC3 Antibody

Catalog Number:

24448

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q13507
Gene ID:7222

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 14 amino acid peptide from near the carboxy terminus of human TRPC3.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

Applications:

ELISA WB IHC

Background:

The mammalian transient receptor potential (TRP) superfamily can be divided into three major families including the "canonical TRP"(TRPC) family. The seven members of this family share the activation through PLC-coupled receptors and have been suggested to be components of receptor-regulated cation channels in different cell types. Furthermore, the members of the TRPC3/6/7 subfamily can be activated by diacylglycerol analogs, suggesting a possible mechanism of activation of these channels by PLC-coupled receptors. TRPC3 encodes a Ca2+-permeant channel that is agonist-activated but not store-operated or directly receptor-activated. TRPC3 physically interacts with TRPC6 and TRPC7 and forms functional tetrameric channels.

References:

appl_detail:

Datasheet PDF