TWEAK Antibody

Catalog Number:

24409

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O43508
Gene ID:407977

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against recombinant human TWEAK.

Purification:

Purified IgG

Specificity/Sensitivity:

Applications:

ELISA WB IHC

Background:

TNF-related weak inducer of apoptosis (TWEAK) is a member of the tumor necrosis factor superfamily (TNFSF) of structurally related cytokines. Like most other members of this family, TWEAK is a cell surface-associated type II transmembrane protein although a smaller, biologically active form can also be generated by cleavage near the cell membrane. TWEAK has multiple biological activities, including stimulation of cell growth and angiogenesis, induction of inflammatory cytokines, in addition to stimulation of apoptosis. The TWEAK signal transduction pathway has not been well established but it appears to signal via TweakR/Fn14 in a manner similar to that described for other TNFSF members that bind receptors lacking death domains.

References:

appl_detail:

Datasheet PDF