DDX3 Antibody

Catalog Number:

24395

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O00571
Gene ID:1654

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide from near the amino terminus of human DDX3.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

DDX3 antibody will detect both DDX3 and DBY.

Applications:

ELISA WB ICC

Background:

DDX3 contains all of the motifs of the DEAD-box family of RNA helicases, including the Asp-Glu-Ala-Asp sequence that gives the protein family its name and distinguishes it from other RNA helicases. DDX3 is localized to the X chromosome and has a highly conserved functional homolog (DBY) on the Y chromosome. DDX3 is thought to be involved in RNA splicing, RNA transport, and translation initiation. It has also been shown to be involved in cell growth control and is deregulated in hepatitis virus-associated hepatocellular carcinoma. Recent experiments suppressing DDX3 expression blocked HIV-1 RNA export from the nucleus, suggesting that DDX3 functions as a shuttling protein that transports the HIV-1 protein Rev and its cofactor CRM1 from the nucleus to the cytoplasm.

References:

appl_detail:

Datasheet PDF