IL-32 Antibody

Catalog Number:

24393

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P24001
Gene ID:9235

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a 16 amino acid peptide from near the center of human IL-32.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This antibody detects the largest isoform of IL-32.

Applications:

ELISA WB

Background:

Interleukin-32 (IL-32) was initially identified as a transcript (NK4) that is selectively expressed in lymphocytes and NK cells and whose expression is increased following activation by IL-2. It was later re-isolated from an IL-18-treated lung carcinoma cell line and re-named IL-32. IL-32 is unusual in that it does not share sequence homology with known cytokine families and is highly expressed in immune tissues, existing in at least four differentially spliced isoforms. Because treatment of human monocytic and mouse macrophage cells with IL-32 induces several proinflammatory cytokines such as TNF-α, IL-8 and MIP-2, and because it is also induced in human peripheral lymphocyte cells after mitogen stimulation and in epithelial cells by IFNγ, it has been suggested that IL-32 may play a role in autoimmune and inflammatory diseases such as rheumatoid arthritis.

References:

appl_detail:

Datasheet PDF