IRAK-M Antibody

Catalog Number:

24128

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9Y616
Gene ID:11213

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK-M.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

IRAK-M antibody has no cross response to IRAK or IRAK2.

Applications:

ELISA WB IHC

Background:

Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.

References:

appl_detail:

Predicted MW: 68 kd

Datasheet PDF