NAK Antibody

Catalog Number:

24127

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9UHD2
Gene ID:29110

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a synthetic peptide corresponding to 17 amino acids form near the carboxy terminus of human NAK/TBK1.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

No cross response to IKKa, IKKb, IKKy, or IKKe.

Applications:

ELISA WB ICC

Background:

Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. Phosphorylation of I-kappaB by IκB kinase (IKK) complex leads to degradation of I-kappaB and activation of NF-κB. The IKK complex contains IKKα, IKKβ, and IKKγ. A novel IKK related kinase was recently identified and designated TBK1 (TANK-binding kinase 1), NAK (NF-κB-activating kinase), and T2K. NAK/TBK1 activates IKKβ through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-κB activation in response to growth factors. NAK/TBK1 functions upstream of NIK and the IKK complex. NAK/TBK1 is also critical in protecting embryonic liver from apoptosis.

References:

appl_detail:

Predicted MW: 84 kd

Datasheet PDF