BACE Antibody

Catalog Number:

24100

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:P56817
Gene ID:23621

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to 17 amino acids at the carboxy terminus of human BACE.

Purification:

Ion exchange chromatography purified

Specificity/Sensitivity:

Applications:

ELISA WB ICC

Background:

Accumulation of the amyloid-beta (Abeta) plaque in the cerebral cortex is a critical event in the pathogenesis of Alzheimer’s disease. Abeta peptide is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is first cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide, which is deposited in the brains of all suffers of Alzheimer’s disease. The long-sought beta-secretase was recently identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and aspartyl protease 2 (Asp2). BACE/Asp2 is a novel transmembrane aspartic protease and colocalizes with APP.

References:

appl_detail:

Predicted MW: 70 kd

Datasheet PDF