DR6 Antibody

Catalog Number:

24077

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O75509
Gene ID:27242

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids 42 to 56 of human DR6 precursor.

Purification:

DEAE purified

Specificity/Sensitivity:

Applications:

ELISA WB

Background:

Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, and DR5 were recently identified. A new death domain containing receptor in the TNFR family was cloned recently and termed DR6 for death receptor-6. Like TNF-R1, DR6 interacts with death domain containing adapter molecule TRADD. Overexpression of DR6 induces apoptosis and activates NF-κB and JNK. DR6 is widely expressed in human tissues and cell lines. The ligand for DR6 has not been identified.

References:

appl_detail:

Predicted MW: 68 kd

Datasheet PDF