DRAK1 Antibody

Catalog Number:

24073

Amount:

100μg

Price:

$319

Swiss-Prot No:

Q9UEE5

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids near the amino terminus of human DRAK1.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

No cross responses to DRAK2, DAP or ZIP kinases.

Applications:

ELISA WB ICC

Background:

Apoptosis is mediated by death domain containing adapter molecules and a caspase family of proteases. Certain serine/threonine protein kinases, such as ASK-1 and RIP, are mediators of apoptosis. Two novel serine/threonine kinases that induce apoptosis were recently identified and designated DRAK1 and DRAK2 for DAP kinase-related apoptosis-inducing protein kinases. DRAKs contain an N-terminal kinase domain and a C-terminal regulation domain. Overexpression of DRAK1 induces apoptosis. DRAKs have high sequence homology to DAP and ZIP kinases, and they represent a novel family of serine/threonine kinases, which mediates apoptosis through their catalytic activities. DRAK1 is located in nucleus and the messenger RNA was ubiquitously expressed in human tissues.

References:

appl_detail:

Predicted MW: 50 kd

Datasheet PDF