DcR3 Antibody

Catalog Number:

24071

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O95407
Gene ID:8771

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids near the amino terminus of human DcR3 precursor.

Purification:

Ion exchange chromatography purified

Specificity/Sensitivity:

Applications:

ELISA WB IHC

Background:

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. Several novel members in the TNFR family including DR3, DR4, DR5, and DR6 were recently discovered and function as cell death receptors. Two decoy receptors, DcR1 and DcR2, were recently identified to compete with DR4 and DR5 for their ligand TRAIL binding. A novel decoy receptor was more recently discovered and designated DcR3 and TR6, respectively,. Unlike DcR1 and DcR2, DcR3 is a soluble rather than a membrane associated molecule. DcR3 binds to FasL and LIGHT and inhibits FasL and LIGHT induced apoptosis. DcR3 transcript is expressed in a number of lung and colon carcinomas and in some normal tissues.

References:

appl_detail:

Predicted MW: 33 kd

Datasheet PDF