IRAK-2 Antibody

Catalog Number:

24064

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O43187
Gene ID:3656

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids near the carboxy terminus of human IRAK2.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

Anti-IRAK2 has no cross response to IRAK.

Applications:

ELISA WB ICC

Background:

The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-κB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-κB activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-κB activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. IRAK2 is expressed in a variety of human tissues.

References:

appl_detail:

Predicted MW: 65 kd

Datasheet PDF