1-832-868-1888
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Catalog Number: |
24063 |
other_names: | IKK beta, I-kappa-B-kinase beta, I-kappa-B-kinase 2 |
Amount: |
100μg |
calculated_mw: | |
host_species: | Rabbit |
Price: |
$319 |
Swiss-Prot No: |
O14920 |
Form of Antibody: |
Supplied in PBS containing 0.02% sodium azide. |
Storage/Stability: |
|
Immunogen: |
Raised against a peptide corresponding to amino acids near the carboxy terminus of human IKK beta (Genbank accession NoO14920), which differs from corresponding murine sequence by one amino acid. |
Purification: |
Affinity chromatography purified via peptide column |
Specificity/Sensitivity: |
This polyclonal antibody has no cross response to IKKa or IKKy. |
Applications: |
ELISA WB ICC |
Background: |
Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα, and bacteria product LPS. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The long-sought IκB kinase (IKK), which phosphorylates IκB, and mediates IκB degradation and NF-κB activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKα and IKKβ). IKKα and IKKβ interact with each other and both are essential for NF-κB activation. IKKβ phosphorylates both IκB-alpha and IκB-beta. IKKβ is expressed in variety of human tissues. |
References: |
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appl_detail: |
Predicted MW: 87 kd |
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