IKK alpha Antibody

Catalog Number:

24062

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O15111
Gene ID:1147

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids 658 to 674 of human IKK alpha, which differs from corresponding murine sequence by one amino acid.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

This polyclonal antibody has no cross response to IKKb or IKKy.

Applications:

ELISA WB ICC

Background:

Nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-κB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFα and bacteria product LPS. NF-κB is associated with IκB proteins in the cell cytoplasm, which inhibit NF-κB activity. The long-sought IκB kinase (IKK), which phosphorylates IκB, and mediates IκB degradation and NF-κB activation, was recently identified by several laboratories. IKK is a serine protein kinase, and the IKK complex contains alpha and beta subunits (IKKα and IKKβ). IKKα and IKKβ interact with each other and both are essential for the NF-κB activation. IKKα specifically phosphorylates IκB-alpha. IKKα is expressed in a variety of human tissues.

References:

appl_detail:

Predicted MW: 87 kd

Datasheet PDF