CIDE-A Antibody

Catalog Number:

24054

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O60543
Gene ID:1149

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids 200 to 214 of mouse CIDE-A.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

It has no cross activity to CIDE-B.

Applications:

ELISA WB IHC

Background:

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE-A is a DFF45-inhibitable effector that promotes cell death and DNA fragmentation. CIDE-A is expressed in many tissues.

References:

appl_detail:

Predicted MW: 25 kd

Datasheet PDF