CIDE-A Antibody

Catalog Number:

24053

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O60543
Gene ID:1149

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids 200 to 217 of human CIDE-A.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

It has no cross activity to CIDE-B.

Applications:

ELISA WB IHC

Background:

Apoptosis is related to many diseases and induced by a family of cell death receptors. Cell death signals are transduced by DD-, DED-, or CARD-containing molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase DFF40/CAD, which is chaperoned and inhibited by DFF45/ICAD. DFF45 related proteins CIDE-A and CIDE-B (for cell death-inducing DFF-like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE-N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE-A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE-A is expressed in many tissues.

References:

appl_detail:

Predicted MW: 23 kd

Datasheet PDF