Caspase-9 Antibody

Catalog Number:

24050

Amount:

100μg

Price:

$319

Swiss-Prot No:

P55211

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids 299 to 318 of human caspase-9.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

It has no cross response to other members in caspase family.

Applications:

ELISA WB ICC

Background:

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. A novel member in the caspase family was recently identified and designated ICE-LAP6, Mch6, and Apaf-3. Caspase-9 and Apaf-1 bind to each other, which leads to caspase-9 activation. Caspase-9 is also activated by granzyme B and CPP32. Activated caspase-9 cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis. Caspase-9 play a central role in cell death induced by a wide variety of apoptosis activators including TNFα, TRAIL, anti-CD-95, FADD, and TRADD. Caspase-9 is expressed in a variety of human tissues.

References:

appl_detail:

Predicted MW: 46 kd

Datasheet PDF