DR3 Antibody

Catalog Number:

24032

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q93038
Gene ID:8718

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids 25 to 40 of human DR3 precusor.

Purification:

DEAE purified

Specificity/Sensitivity:

DR3 has no cross reaction to other death receptors.

Applications:

ELISA WB

Background:

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel cell death receptor was recently identified by several groups independently and designated DR3, Wsl-1, Apo-3, TRAMP and LARD1-5. The ligand for this novel death receptor has been defined as TWEAK, also termed Apo3L. DR3 is highly expressed in the tissues enriched in lymphocytes including PBL, thymus and spleen. Like TNFR1, DR3 induces apoptosis and NF-κB activation.

References:

appl_detail:

Predicted MW: 59 kd

Datasheet PDF