Daxx Antibody

Catalog Number:

24031

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9UER7
Gene ID:1616

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids near the carboxy terminus of human Daxx.

Purification:

DEAE purified

Specificity/Sensitivity:

Applications:

ELISA WB ICC

Background:

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. A novel DD-containing molecule was recently cloned from mouse, human and monkey and designated Daxx. Daxx binds specifically to the Fas death domain and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. Daxx is widely expressed in fetal and adult human and mouse tissues indicating its important function in Fas signaling pathways.

References:

appl_detail:

Predicted MW: 120 kd

Datasheet PDF