FLIP Antibody

Catalog Number:

24029

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O15519
Gene ID:8837

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids near the amino terminus of human FLIP. The sequence is identical in all FLIP splice variants.

Purification:

Affinity chromatography purified via peptide column

Specificity/Sensitivity:

FLIP recognizes all FLIP splice variants including FLIPa, b, and y.

Applications:

ELISA WB IHC IF FC

Background:

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD)- containing adapter molecules and members of the ICE/CED-3 protease family. Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP, respectively. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH and CLARP3-7. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors. Four splice variants of c-FLIPs have been identified and termed FLIPalpha, beta, gamma, and delta, respectively.

References:

appl_detail:

Datasheet PDF