FLIP Antibody

Catalog Number:

24027

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O15519
Gene ID:8837

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids 449 to 465 of mouse FLIPL/CASHa.

Purification:

DEAE purified

Specificity/Sensitivity:

FLIP has short form (FLIPS) and long form (FLIPL) and antibody recognizes the FLIPL only.

Applications:

ELISA WB ICC

Background:

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain (DD) containing adapter molecules and members of the ICE/CED-3 protease family.Caspases-8 (FLICE) and -10 (FLICE2) are two pivotal members in the ICE/CED-3 protease family. FLICE-inhibitory proteins were identified in virus and human and designated v-FLIPs and FLIP respectively. The human FLIP was also cloned by several labs independently and termed Casper , I-FLICE, FLAME-1, CASH, CLARP and MRIT. FLIP contains two death effector domains (DEDs) and a caspase-like domain. FLIP interacts with adapter protein FADD and caspase-8 and 10, and potently inhibits apoptosis induced by all known death receptors CD95, DR3, TRAIL-R and TNFR1.

References:

appl_detail:

Predicted MW: 55 kd

Datasheet PDF