GFR alpha 3 Antibody

Catalog Number:

24021

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O35118
Gene ID:14587

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids from 347 to 360 of murine GFR alpha 3.

Purification:

DEAE purified

Specificity/Sensitivity:

Applications:

ELISA WB IHC

Background:

Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play essential roles in the control of vertebrate neuron survival and differentiation. A new member of the GDNF family was recently identified and designated persephin. Physiological responses to these neurotrophic factors require two receptor subunits, the novel glycosylphosphadidylinositol linked protein GFRα and Ret receptor tyrosine kinase GFRbeta. Following the findings of GFRα-1 and -2, a novel receptor in GFRα family was identified very recently from human and mouse and designated GFRα-3. GFRα-3 binds persephin, thus, persephin, GFRα-3, and Ret PTK form a complex to transduce persephin signal and to mediate persephin function.

References:

appl_detail:

Datasheet PDF