GFR alpha 2 Antibody

Catalog Number:

24020

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O00451
Gene ID:2675

Form of Antibody:

Supplied in PBS containing 0.02% sodium azide.

Storage/Stability:

Immunogen:

Raised against a peptide corresponding to amino acids 377 to 391 of human GFR alpha 2. The amino acid sequences of immunogenic peptide are identical to those of mouse and rat.

Purification:

DEAE purified

Specificity/Sensitivity:

Applications:

ELISA WB ICC

Background:

Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN) play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRalpha, which is a cell surface receptor for NTN. The cDNAs encoding NTNRalpha from human, rat, chicken, and mouse have been cloned recently. NTNRalpha was also termed GDNFRβ, Ret ligand 2 (RETL2) or TGFbeta-related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRα-2 recently. GFRα-2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRα-2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.

References:

appl_detail:

Predicted MW: 52 kd

Datasheet PDF