UNC13(C. elegans)-like antibody

Catalog Number:

23108

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:O14795
Gene ID:10497

Form of Antibody:

Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.

Storage/Stability:

Immunogen:

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 462 and 719 of human UNC13B

Purification:

Purified by antigen-affinity chromatography.

Specificity/Sensitivity:

Applications:

WB IHC

Background:

This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq]

References:

appl_detail:

Predicted MW: 181kd
Western blotting: 1:500-1:3000
Immunohistochemistry: 1:50-1:500

Datasheet PDF