GAD67 antibody

Catalog Number:

22998

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q99259
Gene ID:2571

Form of Antibody:

Supplied in 1XPBS, 40% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.

Storage/Stability:

Immunogen:

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 280 and 582 of GAD1

Purification:

Purified by antigen-affinity chromatography.

Specificity/Sensitivity:

Applications:

WB IF

Background:

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq]

References:

appl_detail:

Predicted MW: 67kd
Western blotting: 1:500-1:3000
Immunofluorescence: 1:100-1:200

Datasheet PDF