caspase-4 antibody

Catalog Number:

22908

Amount:

100μg

Price:

$319

Swiss-Prot No:

NCBI Gene ID: 837
NCBI mRNA#: NM_001225
NCBI Protein#: NP_001216

Form of Antibody:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

A synthesized peptide derived from human Caspase 4

Purification:

Purified by antigen-affinity chromatography.

Specificity/Sensitivity:

Applications:

WB IHC

Background:

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq]

References:

appl_detail:

Predicted MW: 43kd
Western blotting: 1:500-1:2000
Immunohistochemistry: 1:50-1:200

Datasheet PDF