Blood Group Lewis a antibody

Catalog Number:

22719

Amount:

100μg

Price:

$319

Swiss-Prot No:

NCBI Gene ID: 2525
NCBI mRNA#: BC074836
NCBI Protein#: AAH74836

Form of Antibody:

Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

A synthesized peptide derived from human Blood Group Lewis a

Purification:

Purified by antigen-affinity chromatography.

Specificity/Sensitivity:

Applications:

Background:

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq]

References:

appl_detail:

Predicted MW: 42kd
Western blotting: 1:500-1:1000

Datasheet PDF