TOK-1 alpha antibody

Catalog Number:

22674

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot:Q9P287
Gene ID:56647

Form of Antibody:

Supplied in 0.1M Tris-buffered saline with 10% Glycerol (pH7.0). 0.01% Thimerosal was added as a preservative.

Storage/Stability:

Immunogen:

Synthetic peptide contain a sequence corresponding to a region within amino acids 181 and 233 (Q9P287) of BCCIP

Purification:

Purified by antigen-affinity chromatography.

Specificity/Sensitivity:

Applications:

WB IF

Background:

This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq]

References:

appl_detail:

Predicted MW: 36kd
Western blotting: 1:500-1:3000
Immunofluorescence: 1:100-1:200

Datasheet PDF