GIT1 (Ab-383) Antibody

Catalog Number:

21707

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q9Y2X7
NCBI Gene ID: 28964

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.381~385 (H-D-Y-D-S) derived from Human GIT1 .

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total GIT1 protein.

Applications:

WB

Background:

 GTPase-activating protein for the ADP ribosylation factor family. May serve as a scaffold to bring together molecules to form signaling modules controlling vesicle trafficking, adhesion and cytoskeletal organization. Increases the speed of cell migration, as well as the size and rate of formation of protrusions, possibly by targeting PAK1 to adhesions and the leading edge of lamellipodia. Sequesters inactive non-tyrosine-phosphorylated paxillin in cytoplasmic complexes.

Manabe R., Kovalenko M., Webb D.J., Horwitz A.R.J. Cell Sci. 115:1497-1510(2002)

References:

appl_detail:

 Western blotting :1:500~1:1000

Datasheet PDF