IGFBP-3 Antibody

Catalog Number:

21671

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P17936
NCBI Protein: NP_001013416.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.185~189(R-Y-K-V-D) derived from Human IGFBP-3.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total IGFBP-3 protein.

Applications:

WB

Background:

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Roghani M., Segovia B., Whitechurch O., Binoux M.Growth Regul. 1:125-130(1991)
Ikonen M., Liu B., Hashimoto Y., Ma L. Cohen P.Proc. Natl. Acad. Sci. U.S.A. 100:13042-13047(2003)
Zhou W., Ross M.M., Tessitore A. J. Proteome Res. 8:5523-5531(2009)

References:

appl_detail:

Predicted MW: 24-41kd
Western blotting: 1:500~1:1000
 

Datasheet PDF