C-Fos Antibody

Catalog Number:

21667

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P01100
NCBI Protein: NP_005243.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.28~32( S-Y-Y-H-S) derived from Human C-Fos.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total C-Fos protein.

Applications:

WB

Background:

Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.

Okazaki K., Sagata N.EMBO J. 14:5048-5059(1995)
Zhang Y., Feng X.H., Derynck R.Nature 394:909-913(1998)
Bossis G., Malnou C.E., Farras R. Mol. Cell. Biol. 25:6964-6979(2005)

References:

appl_detail:

Predicted MW: 62kd
Western blotting: 1:500~1:1000

Datasheet PDF