Adiponectin Antibody

Catalog Number:

21665

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q15848
NCBI Protein: NP_001171271.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.235~239(T-G-F-L-L) derived from Human Adiponectin.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total Adiponectin protein.

Applications:

WB

Background:

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-a by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Yamauchi T., Kamon J., Waki H. Kadowaki T.Nat. Med. 7:941-946(2001)
Richards A.A., Stephens T., Charlton H.K. Mol. Endocrinol. 20:1673-1687(2006)

References:

appl_detail:

Predicted MW: 27kd
Western blotting: 1:500~1:1000

Datasheet PDF