WASP Antibody

Catalog Number:

21632

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P42768
NCBI Protein: NP_000368.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.289~293 (L-I-Y-D-F) derived from Human WASP.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total WASP protein.

Applications:

WB

Background:

Effector protein for Rho-type GTPases. Regulates actin filament reorganization via its interaction with the Arp2/3 complex. Important for efficient actin polymerization. Possible regulator of lymphocyte and platelet function. Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria.

Kolluri R., Tolias K.F., Carpenter C.L., Rosen F.S. Proc. Natl. Acad. Sci. U.S.A. 93:5615-5618(1996)
Ramesh N., Anton I.M., Hartwig J.H., Geha R.S. Proc. Natl. Acad. Sci. U.S.A. 94:14671-14676(1997)
Cory G.O.C., Cramer R., Blanchoin L., Ridley A.J. Mol. Cell 11:1229-1239(2003)

References:

appl_detail:

Predicted MW: 53kd
Western blotting: 1:500~1:1000

Datasheet PDF