Beclin-1 Antibody

Catalog Number:

21582

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q14457
NCBI Protein: NP_003757.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.69-73( F-I-E-T-P) derived from Human Beclin-1.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total Beclin-1 protein.

Applications:

WB

Background:

Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus.

Sagona A.P., Nezis I.P., Pedersen N.M., Liestol K., Poulton J., Rusten T.E., Skotheim R.I., Raiborg C., Stenmark H.Nat. Cell Biol. 12:362-371(2010)
Sun Q., Fan W., Chen K., Ding X., Chen S., Zhong Q.Proc. Natl. Acad. Sci. U.S.A. 105:19211-19216(2008)

References:

appl_detail:

Predicted MW: 60kd
Western blotting: 1:500~1:1000

Datasheet PDF