Tau Antibody

Catalog Number:

21570

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: P19332
NCBI Protein: NP_058908.2

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa. 725-729(T-G-S-I-D) derived from Rat Tau

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide

Specificity/Sensitivity:

The antibody detects endogenous level of total Tau protein.

Applications:

WB

Background:

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Johnson , G.V. and Stoothoff , W.H. (2004) J. Cell Sci. 117, 5721-5729.
Hanger, D. P. et al. (1998) J. Neurochem. 71, 2465-2476.
Bramblett, G. T. et al. (1993) Neuron 10, 1089-1099.

References:

appl_detail:

Predicted MW: 48 62 78kd
Western blotting: 1:500~1:1000

Datasheet PDF