ABCG2(CD338) Antibody

Catalog Number:

21476

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q9UNQ0
NCBI Protein: NP_004818.2

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.160~164( R-I-N-R-V) derived from Human ABCG2(CD338).

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total ABCG2(CD338) protein.

Applications:

WB

Background:

Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

Henriksen U., Gether U., Litman T.J. Cell Sci. 118:1417-1426(2005) Wakabayashi K., Nakagawa H., Tamura A., Koshiba S., Hoshijima K., Komada M., Ishikawa T. J. Biol. Chem. 282:27841-27846(2007)

References:

appl_detail:

Predicted MW: 65-80kd
Western blotting: 1:500

Datasheet PDF