MCL1 Antibody

Catalog Number:

21440

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q07820
NCBI Protein: NP_068779.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.148~152(N-N-T-S-T) derived from Human MCL1.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total MCL1 protein.

Applications:

WB

Background:

Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.

Bingle C.D., Craig R.W., Swales B.M., Singleton V., Zhou P., Whyte M.K.B.J. Biol. Chem. 275:22136-22146(2000)
Zhang D., Li F., Weidner D., Mnjoyan Z.H., Fujise K.J. Biol. Chem. 277:37430-37438(2002)
Leu J.I.-J., Dumont P., Hafey M., Murphy M.E., George D.L.Nat. Cell Biol. 6:443-450(2004)

References:

appl_detail:

Predicted MW: 42kd
Western blotting: 1:500~1:1000

Datasheet PDF