OCT-4 Antibody

Catalog Number:

21424

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q01860
NCBI Protein: NP_002692.2

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.232~236 (R-K-R-T-S) derived from OCT-4

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total OCT-4 protein.

Applications:

WB

Background:

Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency

Pesce, M. and Scholer, H.R. (2001) Stem Cells 19, 271-278.
Pan, G. and Thomson, J.A. (2007) Cell Res 17, 42-9.
Cauffman, G. et al. (2006) Stem Cells 24, 2685-91.
 

References:

appl_detail:

Predicted MW: 45kd
Western blotting: 1:1000
 

Datasheet PDF