p62Dok(Ab-398) Antibody

Catalog Number:

21269

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot: Q99704
NCBI Protein: NP_001372.1

Form of Antibody:

Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around aa.396~400 (P-I-Y-D-E) derived from Human p62Dok.

Purification:

Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Specificity/Sensitivity:

The antibody detects endogenous level of total p62Dok protein.

Applications:

WB IHC IF

Background:

DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3.

Michael J. Wick,et,al. (2001) J. Biol. Chem; 276: 42843 - 42850.
Paul D. Simoncic, et,al. (2006) Mol. Cell. Biol; 26: 4149 - 4160.
Nadia Dub

References:

appl_detail:

Predicted MW: 62kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200

Datasheet PDF