VEGFR1 (Phospho-Tyr1213) Antibody

Catalog Number:

11985

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P17948;
NCBI Gene#: 2321;
NCBI Protein#: NP_001153392.1

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Tyrosine 1213(V-R-Y(p)-V-N) derived from Human VEGFR1.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous level of VEGFR1 only when phosphorylated at tyrosine 1213.

Applications:

WB

Background:

Receptor for VEGF, VEGFB and PGF. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. Isoform SFlt1 may have an inhibitory role in angiogenesis.

Raghu H, et al. (2012) Mol Oncol 6, 33-47
Ito N, Huang K, Claesson-Welsh L (2001) Cell Signal 13, 849-54
Ito N, Wernstedt C, Engstr?m U, Claesson-Welsh L (1998) J Biol Chem 273, 23410-8

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF