M-CSF Receptor (Phospho-Tyr809) Antibody

Catalog Number:

11906

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P07333;
NCBI Gene#: 1436;
NCBI Protein#: NP_001275634.1

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of tyrosine 809 (S-N-Y(p)-I-V) derived from Human M-CSF Receptor.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous level of M-CSF Receptor only when phosphorylated at tyrosine 809.

Applications:

WB

Background:

Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development.

Sampaio NG, et al. (2011) J Cell Sci 124, 2021-31
21610095 Curated Info
Xiong Y, et al. (2011) J Biol Chem 286, 952-60
21041311 Curated Info
Yu W, et al. (2008) J Leukoc Biol 84, 852-63

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF