EGFR (Phospho-Ser1026) Antibody

Catalog Number:

11902

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: P00533;
NCBI Gene#: 1956;
NCBI Protein#: NP_005219.2

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of serine 1026 (P-S-S(p)-P-S) derived from Human EGFR.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous level of EGFR only when phosphorylated at serine 1026.

Applications:

WB

Background:

Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.

Wu SL, et al. (2006)Mol Cell Proteomics 5, 1610-27
Tong J, et al. (2009) Mol Cell Proteomics 8, 2131-44
Daub H, et al. (2008) Mol Cell 31, 438-48

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF