TPH2 (Phospho-Ser19) Antibody

Catalog Number:

11828

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8IWU9;
NCBI Gene#: 121278;
NCBI Protein#: NP_775489.2.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 19(G-F-S(p)-L-D) derived from Human TPH2.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of TPH2 only when phosphorylated at serine 19.

Applications:

WB

Background:

This gene encodes a member of the pterin-dependent aromatic acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. The human genome contains two related tryptophan hydroxylases, one on chromosome 11p15-p14 and one on chromosome 12q21. This gene is expressed predominantly in the brain stem. Mutations in this gene may be associated with psychiatric diseases such as bipolar affective disorder and major depression.

Walther D.J., Science 299:76-76(2003).
Scherer S.E., Nature 440:346-351(2006).

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF