HDAC7A (Phospho-Ser155) Antibody

Catalog Number:

11823

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q8WUI4;
NCBI Gene#: 51564;
NCBI Protein#: NP_056216.2.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 155(T-V-S(p)-E-P) derived from Human HDAC7A.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of HDAC7A only when phosphorylated at serine 155.

Applications:

WB

Background:

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Walsh M.J., Submitted (FEB-2000).
Zelent A., Submitted (MAY-2003).
Sugano S., Nat. Genet. 36:40-45(2004)

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF