Tip60 (Phospho-Ser90) Antibody

Catalog Number:

11815

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q92993;
NCBI Gene#: 10524;
NCBI Protein#: NP_006379.2.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 90(P-G-S(p)-P-E) derived from Human Tip60.

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of Tip60 only when phosphorylated at serine 90.

Applications:

IHC

Background:

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.

Kamine J., Virology 216:357-366(1996).
Sheridan A.M., Mol. Cell. Biol. 21:4470-4481(2001).
Legube G., Gene 310:161-168(2003).

References:

appl_detail:

Immunohistochemistry: 1:50~1:100

Datasheet PDF