HP1γ (Phospho-Ser93) Antibody

Catalog Number:

11768

Amount:

100μg

Price:

$319

Swiss-Prot No:

Swiss-Prot#: Q13185;
NCBI Gene#: 11335/653972;
NCBI Protein#: NP_009207.2.

Form of Antibody:

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Storage/Stability:

Immunogen:

Peptide sequence around phosphorylation site of Serine 93(R-L-S(p)-L-S) derived from Human HP1γ .

Purification:

Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Specificity/Sensitivity:

The antibody detects endogenous levels of HP1γ only when phosphorylated at serine 93.

Applications:

WB

Background:

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.

Ye Q., J. Biol. Chem. 271:14653-14656(1996).
Ye Q., Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
Koike N., FEBS Lett. 467:17-21(2000)

References:

appl_detail:

Western blotting: 1:500~1:1000

Datasheet PDF